She started her career with anchoring when she was four and her first film was Kanda Naal Mudhal in 2005 when she was 15. Regina’s next was Suryakaanti in Kannada, alongside, Karthik Kumar. In 2009, Regina entered Tollywood with Shiva Manasulo Shruti alongside Mahesh Babu’s brother-in-law Sudheer Babu.